Siblings research paper

Results   Of 95 727 children with older siblings, 994 (%) were diagnosed with ASD and 1929 (%) had an older sibling with ASD. Of those with older siblings with ASD, 134 (%) had ASD, vs 860 (%) children with unaffected siblings ( P  < .001). MMR vaccination rates (≥1 dose) were 84% (n = 78 549) at age 2 years and 92% (n = 86 063) at age 5 years for children with unaffected older siblings, vs 73% (n = 1409) at age 2 years and 86% (n = 1660) at age 5 years for children with affected siblings. MMR vaccine receipt was not associated with an increased risk of ASD at any age. For children with older siblings with ASD, at age 2, the adjusted relative risk (RR) of ASD for 1 dose of MMR vaccine vs no vaccine was (95% CI, -; P  = .25), and at age 5, the RR of ASD for 2 doses compared with no vaccine was (95% CI, -; P  = .07). For children whose older siblings did not have ASD, at age 2, the adjusted RR of ASD for 1 dose was (95% CI, -; P  = .50) and at age 5, the RR of ASD for 2 doses was (95% CI, -; P  = .65).

Siblings research paper

siblings research paper

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